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Tg(tetO-NEFL)173.2Jpj
Transgene Detail
Nomenclature
Symbol: Tg(tetO-NEFL)173.2Jpj
Name: transgene insertion 173.2, Jean-Pierre Julien
MGI ID: MGI:4819012
Synonyms: Tg(hNF-LP22S)
Transgene: Tg(tetO-NEFL)173.2Jpj  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-NEFL)173.2Jpj expresses 1 gene
 
Mutation detailsThe tetracycline responsive element (TRE), minimal CMV promoter fused to the tetracycline operator, drives conditional expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of serine for proline at position 22 (P22S). Three lines were established (173.2, 173.3, and 176). (J:160704)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:160704 Dequen F, et al., Reversal of neuropathy phenotypes in conditional mouse model of Charcot-Marie-Tooth disease type 2E. Hum Mol Genet. 2010 Jul 1;19(13):2616-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory