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Tg(Prnp-APP*)1Hmor
Transgene Detail
Summary
Symbol: Tg(Prnp-APP*)1Hmor
Name: transgene insertion 1, Hiroshi Mori
MGI ID: MGI:4818971
Synonyms: APPE693delta
Transgene: Tg(Prnp-APP*)1Hmor  Location: unknown  
Alliance: Tg(Prnp-APP*)1Hmor page
Transgene
origin
Strain of Origin:  (C57BL/6N x C3H/HeN)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-APP*)1Hmor expresses 1 gene
 
Mutation detailsThe mouse promoter drives expression of the human cDNA with nucleotide deletions that result in the deletion of aspartic acid at position 693 (E693delta). Three lines were generated (lines 1, 2, and 3) with high, low, and intermediate expression levels, respectively. (J:123688)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:123688 Matsuyama S, et al., Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice. Neuroreport. 2007 Jul 2;18(10):1083-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory