Mrtfb^tm2.1Eno
Targeted Allele Detail

Summary

• Symbol: Mrtfb^tm2.1Eno
• Name: myocardin related transcription factor B; targeted mutation 2.1, Eric N Olson
• MGI ID: MGI:4818683
• Synonyms: Mrtfb^F
• Gene: Mrtfb Location: Chr16:13074345-13235393 bp, + strand Genetic Position: Chr16, 9.24 cM
• Alliance: Mrtfb^tm2.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and an frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 8. This exon contains the Srf binding site. Flp mediated recombination removed the neo cassette leaving exon 8 floxed. (J:161853)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrtfb Mutation: 68 strains or lines available

References

• Original: J:161853 Mokalled MH, et al., Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010 Jul;137(14):2365-74
• All: 14 reference(s)