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Mkl2tm2.1Eno
Targeted Allele Detail
Nomenclature
Symbol: Mkl2tm2.1Eno
Name: MKL/myocardin-like 2; targeted mutation 2.1, Eric N Olson
MGI ID: MGI:4818683
Synonyms: MrtfbF
Gene: Mkl2  Location: Chr16:13256481-13417529 bp, + strand  Genetic Position: Chr16, 9.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161853
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 8 and an frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 8. This exon contains the Srf binding site. Flp mediated recombination removed the neo cassette leaving exon 8 floxed. (J:161853)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mkl2 Mutation:  30 strains or lines available
References
Original:  J:161853 Mokalled MH, et al., Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010 Jul;137(14):2365-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory