Sh3kbp1^tm1Ivdi
Targeted Allele Detail

Summary

• Symbol: Sh3kbp1^tm1Ivdi
• Name: SH3-domain kinase binding protein 1; targeted mutation 1, Ivan Dikic
• MGI ID: MGI:4818424
• Synonyms: Cin85^-, delta Ex2
• Gene: Sh3kbp1 Location: ChrX:158409888-158758916 bp, + strand Genetic Position: ChrX, 73.65 cM
• Alliance: Sh3kbp1^tm1Ivdi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ/neo-cassette replaced exon 2 by homologous recombination. Loss of CIN85-xl and CIN85-l isoforms in brain, thymus and spleen was confirmed by western blot. LacZ was not expressed. (J:162088)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3kbp1 Mutation: 6 strains or lines available

References

• Original: J:162088 Shimokawa N, et al., CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J. 2010 Jul 21;29(14):2421-32
• All: 3 reference(s)