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Sh3kbp1tm1Ivdi
Targeted Allele Detail
Nomenclature
Symbol: Sh3kbp1tm1Ivdi
Name: SH3-domain kinase binding protein 1; targeted mutation 1, Ivan Dikic
MGI ID: MGI:4818424
Synonyms: Cin85-, delta Ex2
Gene: Sh3kbp1  Location: ChrX:159626892-159975920 bp, + strand  Genetic Position: ChrX, 73.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162088
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA LacZ/neo-cassette replaced exon 2 by homologous recombination. Loss of CIN85-xl and CIN85-l isoforms in brain, thymus and spleen was confirmed by western blot. LacZ was not expressed. (J:162088)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh3kbp1 Mutation:  1 strain or line available
References
Original:  J:162088 Shimokawa N, et al., CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J. 2010 Jul 21;29(14):2421-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory