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Del(10Prmt2-Pdxk)4Yey
Targeted Allele Detail
Nomenclature
Symbol: Del(10Prmt2-Pdxk)4Yey
Name: deletion, Chr 10, Y Eugene Yu 4
MGI ID: MGI:4818358
Synonyms: Del(10)1Yey, Del(10Prmt2-Pdxk)1Yey, Del4Yey, Del5Yey, Df(10)1Yey, Df(Prmt2-Pdxk)1Yey
Gene: Del(10Prmt2-Pdxk)4Yey  Location: Chr10:76043060-78300782 bp  Genetic Position: Chr10, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161398
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(10Prmt2-Pdxk)4Yey involves 85 genes/genome features (Gm19376, n-TAagc5, n-R5s77 ...) View all
 
Mutation detailsCre mediated chromosomal rearrangement between loxP sites in regions proximal to Prmt2 and distal to Pdxk resulted in deletion of the genes, including Prmt2 and Pdxk, in this approximately 2.3 Mb region that is syntenic with the distal part of human 21q22.3. (J:161398)
Generation of the Del(10Prmt2-Pdxk)4Yey deletion
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(10Prmt2-Pdxk)4Yey Mutation:  1 strain or line available
References
Original:  J:161398 Yu T, et al., Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun;21(5-6):258-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory