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Hoxc10tm1Emca
Targeted Allele Detail
Nomenclature
Symbol: Hoxc10tm1Emca
Name: homeobox C10; targeted mutation 1, Ellen M Carpenter
MGI ID: MGI:4462853
Synonyms: Hoxc10-
Gene: Hoxc10  Location: Chr15:102966796-102971893 bp, + strand  Genetic Position: Chr15, 58.03 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161095
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 157 bp deletion was made in the second exon to remove all three alpha-helices of the homeodomain, and the deleted sequence was replaced with an inframe fusion of LacZ and neoR into the coding sequence of exon 2. (J:161095)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 35 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxc10 Mutation:  2 strains or lines available
References
Original:  J:161095 Hostikka SL, et al., Axial and appendicular skeletal transformations, ligament alterations, and motor neuron loss in Hoxc10 mutants. Int J Biol Sci. 2009;5(5):397-410
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory