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Targeted Allele Detail
Symbol: Grb2tm1.1Hua
Name: growth factor receptor bound protein 2; targeted mutation 1.1, Hua Gu
MGI ID: MGI:4462852
Synonyms: Grb2f
Gene: Grb2  Location: Chr11:115644045-115708597 bp, - strand  Genetic Position: Chr11, 80.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:161294
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette with a 5' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 4. Cre mediated recombination removed the neo cassette leaving exon 4 floxed. (J:161294)
Generation of the Grb2tm1.1Hua allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:  34 strains or lines available
Original:  J:161294 Jang IK, et al., Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10620-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory