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Grb2tm1.1Hua
Targeted Allele Detail
Nomenclature
Symbol: Grb2tm1.1Hua
Name: growth factor receptor bound protein 2; targeted mutation 1.1, Hua Gu
MGI ID: MGI:4462852
Synonyms: Grb2f
Gene: Grb2  Location: Chr11:115644045-115708597 bp, - strand  Genetic Position: Chr11, 80.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161294
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette with a 5' loxP site was inserted upstream of exon 4 and an additional loxP site was inserted downstream of exon 4. Cre mediated recombination removed the neo cassette leaving exon 4 floxed. (J:161294)
Generation of the Grb2tm1.1Hua allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grb2 Mutation:  34 strains or lines available
References
Original:  J:161294 Jang IK, et al., Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10620-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory