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Targeted Allele Detail
Symbol: Del(7Slx1b-Sept1)4Aam
Name: deletion, Chr 7, Alea A Mills 4
MGI ID: MGI:4462822
Synonyms: 16p11.2 df, Del(7)4Aam
Gene: Del(7Slx1b-Sept1)4Aam  Location: Chr7:126689468-127233130 bp  Genetic Position: Chr7, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:176335
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Del(7Slx1b-Sept1)4Aam involves 50 genes/genome features (Gm19288, Gm15676, Gm6939 ...) View all
Mutation detailsChromosome-engineering cassettes were inserted into mouse Chromosome 7, bracketing a span of approximately 0.39 Mb between the SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (Smg1) and the aldolase A, fructose-bisphosphate (Aldoa) loci. The cassette placed at the proximal locus contained Smg1, a puromycin resistance gene, a loxP site, a 3' portion of an hprt minigene and an agouti transgene. The cassette placed at the distal locus contained the Aldoa gene, a tyrosinase minigene, a 5' portion of an hprt minigene, a loxP site and neomycin resistance gene. Double-targeted ES cells were subjected to transient cre recombinase expression with subsequent selection of recombinants by using hypoxanthine aminopterin thymidine (HAT) media to delete the targeted region. (J:176335)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(7Slx1b-Sept1)4Aam Mutation:  1 strain or line available
Original:  J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 3;
All:  10 reference(s)

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MGI 6.11
The Jackson Laboratory