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Del(7Slx1b-Sept1)4Aam
Targeted Allele Detail
Nomenclature
Symbol: Del(7Slx1b-Sept1)4Aam
Name: deletion, Chr 7, Alea A Mills 4
MGI ID: MGI:4462822
Synonyms: 16p11.2 df, Del(7)4Aam
Gene: Del(7Slx1b-Sept1)4Aam  Location: Chr7:126689468-127218498 bp  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176335
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
  Del(7Slx1b-Sept1)4Aam involves 50 genes/genome features (Gm19288, Gm6939, Slx1b ...) View all
 
Mutation detailsChromosome-engineering cassettes were inserted into mouse Chromosome 7, bracketing a span of approximately 0.39 Mb between the SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (Smg1) and the aldolase A, fructose-bisphosphate (Aldoa) loci. The cassette placed at the proximal locus contained Smg1, a puromycin resistance gene, a loxP site, a 3' portion of an hprt minigene and an agouti transgene. The cassette placed at the distal locus contained the Aldoa gene, a tyrosinase minigene, a 5' portion of an hprt minigene, a loxP site and neomycin resistance gene. Double-targeted ES cells were subjected to transient cre recombinase expression with subsequent selection of recombinants by using hypoxanthine aminopterin thymidine (HAT) media to delete the targeted region. (J:176335)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(7Slx1b-Sept1)4Aam Mutation:  1 strain or line available
References
Original:  J:176335 Horev G, et al., Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A. 2011 Oct 3;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory