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Ppibtm1.1Rjb
Targeted Allele Detail
Nomenclature
Symbol: Ppibtm1.1Rjb
Name: peptidylprolyl isomerase B; targeted mutation 1.1, Richard J Bram
MGI ID: MGI:4462803
Gene: Ppib  Location: Chr9:66060222-66066623 bp, + strand  Genetic Position: Chr9, 35.69 cM
Decreased body size and kyphosis in Ppibtm1.1Rjb/Ppibtm1.1Rjb mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161748
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele was created by crossing Ppibtm1Rjb with mice bearing MMTV-Cre transgene to remove the third exon franked by targeted loxP sites. Complete loss of gene product was confirmed by western blot in thymocytes. This is a null allele. (J:161748)
Generation of the Ppibtm1Rjb and Ppibtm1.1Rjb alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppib Mutation:  13 strains or lines available
References
Original:  J:161748 Choi JW, et al., Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009 Dec;5(12):e1000750
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory