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Glultm3Whla
Targeted Allele Detail
Nomenclature
Symbol: Glultm3Whla
Name: glutamate-ammonia ligase (glutamine synthetase); targeted mutation 3, Wouter H Lamers
MGI ID: MGI:4462791
Synonyms: GSfl
Gene: Glul  Location: Chr1:153899944-153909723 bp, + strand  Genetic Position: Chr1, 65.43 cM, cytoband G2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162067
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsOne loxP site was inserted in the 3' end of intron 1. An FRT flanked Pgk-neo-PgkTkselection casette was inserted along with a second loxP site 600 bp downstream from exon 7. The FRT flanked selection cassette was removed by transient transfection using an FLPe expression vector. (J:162067)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glul Mutation:  8 strains or lines available
References
Original:  J:162067 He Y, et al., Glutamine synthetase deficiency in murine astrocytes results in neonatal death. Glia. 2010 Apr 15;58(6):741-54
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory