About   Help   FAQ
Targeted Allele Detail
Symbol: Acdtm1.1Blas
Name: adrenocortical dysplasia; targeted mutation 1.1, Maria A Blasco
MGI ID: MGI:4462417
Synonyms: Tpp1flox
Gene: Acd  Location: Chr8:105698155-105701228 bp, - strand  Genetic Position: Chr8, 53.04 cM
Germline Transmission:  Earliest citation of germline transmission: J:160600
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT flanked neo cassette and a loxP site were inserted in exon 1 and a second loxP site was inserted in intron 4. The neomycin selection cassette was excised using Flp recombinase. (J:160600)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acd Mutation:  16 strains or lines available
Original:  J:160600 Tejera AM, et al., TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell. 2010 May 18;18(5):775-89
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory