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Targeted Allele Detail
Symbol: Whrntm1Tili
Name: whirlin; targeted mutation 1, Tiansen Li
MGI ID: MGI:4462398
Synonyms: Whrnneo
Gene: Whrn  Location: Chr4:63414910-63495991 bp, - strand  Genetic Position: Chr4, 33.97 cM, cytoband C1
Morphological defects around the periciliary membrane complex in Whrntm1Tili/Whrntm1Tili photoreceptors

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:160677
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Modified isoform(s), Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 1 was replaced with a neo cassette. The absence of long form protein expression was confirmed by western blot analysis on retina extracts. The short form is expressed. (J:160677)
Generation of the Whrntm1Tili allele
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Whrn Mutation:  21 strains or lines available
Original:  J:160677 Yang J, et al., Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010;6(5):e1000955
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory