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Chrna1tm1Klee
Targeted Allele Detail
Nomenclature
Symbol: Chrna1tm1Klee
Name: cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:4462390
Synonyms: AChRalpha1-
Gene: Chrna1  Location: Chr2:73563215-73580338 bp, - strand  Genetic Position: Chr2, 43.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161300
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by immunohistochemistry on hindlimb muscle. (J:161300)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrna1 Mutation:  6 strains or lines available
References
Original:  J:161300 An MC, et al., Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory