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Elovl4tm2Kzh
Targeted Allele Detail
Nomenclature
Symbol: Elovl4tm2Kzh
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; targeted mutation 2, Kang Zhang
MGI ID: MGI:4462372
Synonyms: Elovl4270x
Gene: Elovl4  Location: Chr9:83778692-83806277 bp, - strand  Genetic Position: Chr9, 45.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161118
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsTyrosine codon Y270 in exon 6 was mutated to encode a stop codon. A floxed neomycin resistance cassette was inserted following the mutated codon 270. (J:161118)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elovl4 Mutation:  23 strains or lines available
References
Original:  J:161118 Cameron DJ, et al., Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int J Biol Sci. 2007;3(2):111-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory