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Cacna1ctm1.1Knt
Targeted Allele Detail
Nomenclature
Symbol: Cacna1ctm1.1Knt
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 1.1, Jean-Pierre Kinet
MGI ID: MGI:4462362
Synonyms: Cav1.2loxP
Gene: Cacna1c  Location: Chr6:118587240-119196890 bp, - strand  Genetic Position: Chr6, 55.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159698
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 14, and a loxP site was inserted downstream of exon 15. Flp mediated recombination removed the neo cassette leaving exons 14 and 15 floxed. (J:159698)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1c Mutation:  9 strains or lines available
References
Original:  J:159698 Jeon D, et al., Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci. 2010 Apr;13(4):482-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory