Tg(Adipoq-cre)#Pesch
Transgene Detail

Summary

• Symbol: Tg(Adipoq-cre)#Pesch
• Name: transgene insertion, Philipp E Scherer
• MGI ID: MGI:4462047
• Synonyms: 5.4-kb Cre
• Transgene: Tg(Adipoq-cre)#Pesch Location: unknown
• Alliance: Tg(Adipoq-cre)#Pesch page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Adipoq-cre)#Pesch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Adipoq

• Mutation details: A 5.4-kb promoter construct containing a 4.9-kb upstream adiponectin promoter sequence, the first exon, 200 bp from the 5' end of intron 1, 200 bp from the 3' end of intron 1, and a partial fragment of the second exon was generated. The endogenous ATG in the exon 2 fragment was mutated to ATA to facilitate correct translation initiation of the transgene. The construct was fused to the cre recombinase open reading frame and the linearized fragment was microinjected into FVB pronuclei. Founders were backcrossed to FVB mice. No line numbers were specified. (J:160881)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Adipoq (species not specified) Summary of all recombinase alleles driven by Adipoq. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:160881 Wang ZV, et al., Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology. 2010 Jun;151(6):2933-9
• All: 19 reference(s)