About   Help   FAQ
Ttll1tm1Seto
Targeted Allele Detail
Nomenclature
Symbol: Ttll1tm1Seto
Name: tubulin tyrosine ligase-like 1; targeted mutation 1, Mitsutoshi Setou
MGI ID: MGI:4461777
Gene: Ttll1  Location: Chr15:83483772-83510893 bp, - strand  Genetic Position: Chr15, 39.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161297
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on trachea and lung extracts. (J:161297)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttll1 Mutation:  8 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Primary Ciliary Dyskinesia (J:161297)

References
Original:  J:161297 Ikegami K, et al., Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory