Tmc4^{tm1e(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Tmc4^{tm1e(EUCOMM)Hmgu}
• Name: transmembrane channel-like gene family 4; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:4461501
• Gene: Tmc4 Location: Chr7:3668790-3680522 bp, - strand Genetic Position: Chr7, 2.11 cM
• IMPC: Tmc4 gene page

Mutation origin

• Mutant Cell Lines: HEPD0575_7_B03, HEPD0575_7_D02, HEPD0575_7_D04, HEPD0575_7_E01, HEPD0575_7_E02, HEPD0575_7_F01, HEPD0575_7_H03
• Germline Transmission: Unknown
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 3675555 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmc4 Mutation: 25 strains or lines available

References

• Original: J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015
• All: 1 reference(s)