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Gt(ROSA)26Sortm5(ACTB-tTA)Luo
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm5(ACTB-tTA)Luo
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Liqun Luo
MGI ID: MGI:4461408
Synonyms: ROSA26-ZtTA, ZtTA
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161840
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Reporter, Transactivator)
Mutation:    Insertion
 
Mutation detailsThe pCA-ZtTA construct was designed with a CMV enhancer/chicken beta-actin core promoter (pCA), a loxP-flanked beta-geo (lacZ-neomycin phosphotransferase fusion) transcriptional STOP cassette, the tetracycline-controlled transactivator protein (tTA or "Tet-Off") open reading frame, and an SV40 T-antigen poly(A) signal. This pCA-ZtTA construct was subcloned into the pROSA26-PA targeting vector to generate the final targeting construct pROSA26-ZtTA. (J:161840)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  444 strains or lines available
References
Original:  J:161840 Li L, et al., Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS One. 2010;5(7):e11503
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory