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Targeted Allele Detail
Symbol: Dp(17Abcg1-Rrp1b)3Yey
Name: duplication, Chr 17, Y Eugene Yu 3
MGI ID: MGI:4461399
Synonyms: Dp(17)1Yey, Dp(17Abcg1-Rrp1b)1Yey, Dp3Yey, Ts3Yey
Gene: Dp(17Abcg1-Rrp1b)3Yey  Location: Chr17:31057698-32062865 bp  Genetic Position: Chr17, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:161325
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Not Applicable)
Mutation:    Duplication
  Dp(17Abcg1-Rrp1b)3Yey involves 28 genes/genome features (Abcg1, Gm25447, Tff3 ...) View all
Mutation detailsCre mediated chromosomal rearrangement between loxP sites in regions proximal to Abcg1 and distal to Rrp1b results in duplication of the genes, including Abcg1 and Rrp1b, in this approximately 1.1 Mb region that is syntenic with the proximal part of human 21q22.3. (J:161325)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(17Abcg1-Rrp1b)3Yey Mutation:  1 strain or line available
Original:  J:161325 Yu T, et al., A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet. 2010 Jul 15;19(14):2780-91
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory