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Carftm1.1Aew
Targeted Allele Detail
Nomenclature
Symbol: Carftm1.1Aew
Name: calcium response factor; targeted mutation 1.1, Anne West
MGI ID: MGI:4461230
Gene: Carf  Location: Chr1:60098247-60153953 bp, + strand  Genetic Position: Chr1, 30.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160811
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA FRT-flanked Neo cassette and a single loxP site were placed 5' to exon 8 and a second loxP site was placed at the 3' the end of exon 8. The selection cassette and exon 8 were removed by flp and cre mediated recombination respectively. A shorter mRNA is produced consistent with the deletion of exon 8. (J:160811)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Carf Mutation:  28 strains or lines available
References
Original:  J:160811 McDowell KA, et al., Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010 Jun 2;30(22):7453-65
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory