About   Help   FAQ
Apctm1.1Tyj
Targeted Allele Detail
Summary
Symbol: Apctm1.1Tyj
Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Tyler Jacks
MGI ID: MGI:4461178
Synonyms: Apcdeltae1-15
Gene: Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance: Apctm1.1Tyj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160399
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre mediated recombination removed exons 1 - 15. This allele is derived from Apctm1Tyj. Quantitative RT-PCR confirms the expected 50% reduction in expression in colons from heterozygous mice. (J:160399)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  154 strains or lines available
References
Original:  J:160399 Cheung AF, et al., Complete deletion of Apc results in severe polyposis in mice. Oncogene. 2010 Mar 25;29(12):1857-64
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory