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Targeted Allele Detail
Symbol: Apctm1.1Tyj
Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Tyler Jacks
MGI ID: MGI:4461178
Synonyms: Apcdeltae1-15
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:160399
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre mediated recombination removed exons 1 - 15. This allele is derived from Apctm1Tyj. Quantitative RT-PCR confirms the expected 50% reduction in expression in colons from heterozygous mice. (J:160399)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  58 strains or lines available
Original:  J:160399 Cheung AF, et al., Complete deletion of Apc results in severe polyposis in mice. Oncogene. 2010 Mar 25;29(12):1857-64
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory