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Pla2g3tm1Murm
Targeted Allele Detail
Summary
Symbol: Pla2g3tm1Murm
Name: phospholipase A2, group III; targeted mutation 1, Makoto Murakami
MGI ID: MGI:4461174
Gene: Pla2g3  Location: Chr11:3438284-3449350 bp, + strand  Genetic Position: Chr11, 2.45 cM
Alliance: Pla2g3tm1Murm page
Sperm dysfunction of Pla2g3tm1Murm/Pla2g3tm1Murm mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161462
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exons (Exon 2-4) encompassing the catalytic domain of the gene were replaced with a neomycin resistance cassette. mRNA expression was undetectable in the heart, kidney and liver from homozygous mutant mice. Immunohistochemical staining of epididymis showed the absence of staining in the spermatozoa, luminal space, and luminal cilia on the epithelium in the caput and corpus of the epididymis. (J:161462)
Generation of the Pla2g3tm1Murm allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g3 Mutation:  18 strains or lines available
References
Original:  J:161462 Sato H, et al., Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice. J Clin Invest. 2010 May 3;120(5):1400-14
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory