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Targeted Allele Detail
Symbol: Tnfrsf1atm2.1Rsie
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 2.1, Richard M Siegel
MGI ID: MGI:4461135
Synonyms: TNFR1C33Y
Gene: Tnfrsf1a  Location: Chr6:125349362-125362484 bp, + strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:160543
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 2 was replaced with a floxed neo cassette and modified exon 2 in which nucleotide substitutions result in the amino acid substitution of tyrosine for cysteine at position 33 (C33Y), mimicking a mutation associated with TNFR-associated periodic syndrome (TRAPS). Cre mediated recombination removes the neo cassette. (J:160543)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  33 strains or lines available
Original:  J:160543 Simon A, et al., Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9801-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory