Klrg1^tm1Hpi
Targeted Allele Detail

Summary

• Symbol: Klrg1^tm1Hpi
• Name: killer cell lectin-like receptor subfamily G, member 1; targeted mutation 1, Hanspeter Pircher-Hpi
• MGI ID: MGI:4460771
• Gene: Klrg1 Location: Chr6:122247555-122259792 bp, - strand Genetic Position: Chr6, 57.52 cM
• Alliance: Klrg1^tm1Hpi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160955
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A neomycin LacZ cassette was instered within exon 3 by homologous recombination. Northern blot analysis of spleen cells from lymphocytic choriomeningitis virus (LCMV)-infected mice showed that mRNA was not expressed. (J:160955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klrg1 Mutation: 22 strains or lines available

References

• Original: J:160955 Grundemann C, et al., The NK receptor KLRG1 is dispensable for virus-induced NK and CD8+ T-cell differentiation and function in vivo. Eur J Immunol. 2010 May;40(5):1303-14
• All: 3 reference(s)