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Msh2tm3.1Rak
Targeted Allele Detail
Nomenclature
Symbol: Msh2tm3.1Rak
Name: mutS homolog 2 (E. coli); targeted mutation 3.1, Raju Kucherlapati
MGI ID: MGI:4460264
Synonyms: Msh2G674D
Gene: Msh2  Location: Chr17:87672330-87723713 bp, + strand  Genetic Position: Chr17, 57.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161577
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neo cassette was inserted upstream of modified exon 13 in which nucleotide substitutions (GGT to GAC) results in the amino acid substitution of aspartic acid for glycine at position 674 (G674D). Cre mediated recombination removed the neo cassette. (J:161577)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msh2 Mutation:  44 strains or lines available
References
Original:  J:161577 Kucherlapati MH, et al., An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. Gastroenterology. 2010 Mar;138(3):993-1002.e1
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory