Pik3c3^tm1Fawa
Targeted Allele Detail

Summary

• Symbol: Pik3c3^tm1Fawa
• Name: phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1, Fan Wang
• MGI ID: MGI:4459941
• Synonyms: Pik3c3^flox
• Gene: Pik3c3 Location: Chr18:30405800-30481179 bp, + strand Genetic Position: Chr18, 17.41 cM
• Alliance: Pik3c3^tm1Fawa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17, and an frt flanked neo cassette with a 3' loxP site was inserted downstream of exon 18. The frt sites were mutated and could not be used to remove the neo cassette, which remains intact. (J:160568)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3c3 Mutation: 45 strains or lines available

References

• Original: J:160568 Zhou X, et al., Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9
• All: 10 reference(s)