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Targeted Allele Detail
Symbol: Hif1antm1.2Rsjo
Name: hypoxia-inducible factor 1, alpha subunit inhibitor; targeted mutation 1.2, Randall S Johnson
MGI ID: MGI:4459899
Synonyms: FIHdelta2
Gene: Hif1an  Location: Chr19:44562854-44576274 bp, + strand  Genetic Position: Chr19, 37.98 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:160941
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted within intron 1, with an additional loxP site with intron 2. The selection cassette and exon 2 were removed by cre mediated recombination. Western blot confirmed absence of protein in whole embryo lysates. (J:160941)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 71 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hif1an Mutation:  10 strains or lines available
Original:  J:160941 Zhang N, et al., The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 5;11(5):364-78
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory