Ehmt2^tm1.1Cza
Targeted Allele Detail

Summary

• Symbol: Ehmt2^tm1.1Cza
• Name: euchromatic histone lysine N-methyltransferase 2; targeted mutation 1.1, Colby Zaph
• MGI ID: MGI:4459641
• Synonyms: G9a^fl
• Gene: Ehmt2 Location: Chr17:35117445-35133028 bp, + strand Genetic Position: Chr17, 18.45 cM
• Alliance: Ehmt2^tm1.1Cza page

Goblet cell hyperplasia in response to T. muris infection in Ehmt2^tm1.1Cza/Ehmt2^tm1.1Cza Tg(VAV1-cre)1Graf/0 mice and treatment with an anti-IFN-gamma antibody fails to recover the hyperplasia

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160938
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: LoxP sites were placed within intron 3 and intron 20. A FRT-flanked Neo cassette was also introduced into inton 20 by homologous recombination. The selection cassette was removed by flp mediated recombination. (J:160938)

Generation of the Ehmt2^tm1.1Cza allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehmt2 Mutation: 55 strains or lines available

References

• Original: J:160938 Lehnertz B, et al., Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function. J Exp Med. 2010 May 10;207(5):915-22
• All: 5 reference(s)