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Targeted Allele Detail
Symbol: Hes5tm1Kag
Name: hes family bHLH transcription factor 5; targeted mutation 1, Ryoichiro Kageyama
MGI ID: MGI:4459527
Synonyms: Hes5-nlsLacZ
Gene: Hes5  Location: Chr4:154960923-154962371 bp, + strand  Genetic Position: Chr4, 86.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:159019
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the Hes5 gene was replaced by the IRES-nls-LacZ expression cassette.by homologous recombination. (J:159019)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Hes5 Mutation:  15 strains or lines available
Original:  J:159019 Imayoshi I, et al., Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. J Neurosci. 2010 Mar 3;30(9):3489-98
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory