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Targeted Allele Detail
Symbol: Del(2Nespas-Gnas)1Hju
Name: deletion, Chr 2, Harald Juppner 1
MGI ID: MGI:4459474
Synonyms: deltaNesp55m, deltaNesp55p, Gnas/Nespastm1.1Hju
Gene: Del(2Nespas-Gnas)1Hju  Location: unknown  Genetic Position: Chr2, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:160293
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
  Del(2Nespas-Gnas)1Hju involves 2 genes/genome features (Nespas, Gnas) View all
Mutation detailsA self-excising neo cassette with a testes specific cre (tACE) replaced a 4.3 kb genomic segment spanning exons 1 and 2 of Gnas and exon 2 through part of exon 4 of Nespas. Cre mediated recombination removed the neo cassette. (J:160293)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(2Nespas-Gnas)1Hju Mutation:  0 strains or lines available
Original:  J:160293 Frohlich LF, et al., Targeted deletion of the Nesp55 DMR defines another Gnas imprinting control region and provides a mouse model of autosomal dominant PHP-Ib. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9275-80
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory