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Dot1ltm1Tche
Targeted Allele Detail
Summary
Symbol: Dot1ltm1Tche
Name: DOT1 like histone lysine methyltransferase; targeted mutation 1, Taiping Chen
MGI ID: MGI:4459467
Synonyms: Dot1L3lox, DOT1Lbetagal
Gene: Dot1l  Location: Chr10:80591040-80631295 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Dot1ltm1Tche page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161427
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 5 and a floxed beta-geo cassette was inserted downstream of exon 6. (J:161427)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 13 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dot1l Mutation:  69 strains or lines available
References
Original:  J:161427 Jones B, et al., The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet. 2008;4(9):e1000190
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory