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Transgene Detail
Symbol: Tg(PLP1*)4Rsj
Name: transgene insertion 4, Ravina Simons Johnson
MGI ID: MGI:4459455
Synonyms: ND4
Transgene: Tg(PLP1*)4Rsj  Location: unknown  
Strain of Origin:  CD-1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PLP1*)4Rsj expresses 1 gene
Mutation detailsA 2.95 kb fragment of the 5' UTR of the human PLP gene drives expression of a cDNA encoding for the DM-20 isoform of human PLP. The cDNA is followed by the small tumor (t) antigen splicing signals and early region polyadenylation signal of SV40. This line contains about 70 copies of the transgene. Northern blot analysis detected expression of the transgene in the brain but not in the liver or kidney. Northern blot analysis also indicated a reduction in the expression of the endogenous Plp1 gene. (J:24069, J:162843)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:161344 Mastronardi FG, et al., Demyelination in a transgenic mouse: a model for multiple sclerosis. J Neurosci Res. 1993 Oct 15;36(3):315-24
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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