Tg(PLP1*)4Rsj
Transgene Detail

Nomenclature

• Symbol: Tg(PLP1*)4Rsj
• Name: transgene insertion 4, Ravina Simons Johnson
• MGI ID: MGI:4459455
• Synonyms: ND4
• Transgene: Tg(PLP1*)4Rsj Location: unknown

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PLP1*)4Rsj expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Homolog in Mouse	Note
  human	PLP1 (5354)	Plp1

• Mutation details: A 2.95 kb fragment of the 5' UTR of the human PLP gene drives expression of a cDNA encoding for the DM-20 isoform of human PLP. The cDNA is followed by the small tumor (t) antigen splicing signals and early region polyadenylation signal of SV40. This line contains about 70 copies of the transgene. Northern blot analysis detected expression of the transgene in the brain but not in the liver or kidney. Northern blot analysis also indicated a reduction in the expression of the endogenous Plp1 gene. (J:24069, J:162843)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:161344 Mastronardi FG, et al., Demyelination in a transgenic mouse: a model for multiple sclerosis. J Neurosci Res. 1993 Oct 15;36(3):315-24
• All: 12 reference(s)