Il13tm1(YFP/cre)Lky
Targeted Allele Detail
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Symbol: |
Il13tm1(YFP/cre)Lky |
Name: |
interleukin 13; targeted mutation 1, Richard M Locksley |
MGI ID: |
MGI:4459318 |
Synonyms: |
YetCre-13 |
Gene: |
Il13 Location: Chr11:53522151-53525529 bp, - strand Genetic Position: Chr11, 31.98 cM
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Alliance: |
Il13tm1(YFP/cre)Lky page
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Allele Type: |
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Targeted (No functional change, Recombinase, Reporter) |
Mutation: |
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Insertion
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Il13tm1(YFP/cre)Lky expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Il13 (MGI:96541) |
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Mutation details: A targeting construct containing a bicistronic reporter/recombinase cassette (loxP-Neo-loxP IRES-YFP-cre cassette and DTA negative-selection cassette with appropriate homology arms) was electroporated into ES cells containing a Prm-cre transgene. Homologous recombination resulted in insertion of the IRES-YFP-cre sequence between the translational stop codon and the 3'UTR of the Il13 gene, preserving the normal function of the gene yet allowing expression of the YFP/cre fusion protein. The floxed Neo cassette was deleted in the male germline (by Prm-cre) when chimeras were bred to wild-type females.
(J:161387)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Il13
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:161387 Price AE, et al., Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11489-94 |
All: |
21 reference(s) |
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