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Tg(Mbp-Pad2)28Fgm
Transgene Detail
Nomenclature
Symbol: Tg(Mbp-Pad2)28Fgm
Name: transgene insertion 28, Fabrizio G Mastronardi
MGI ID: MGI:4459094
Synonyms: PD2
Transgene: Tg(Mbp-Pad2)28Fgm  Location: unknown  
Transgene
origin
Strain of Origin:  CD-1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Mbp-Pad2)28Fgm expresses 1 gene
 
Mutation detailsA 1.9 kb fragment of the mouse Mbp promoter (from the pMG2 plasmid) drives expression of a 2.3 kb cDNA fragment encoding rat Pad2. This line contains 15 copies of the transgene. Immunohistochemical analysis indicates increased expression in the white matter tracts of the corpus callosum. Immunoslot blot analysis of whole brain homogenates also indicates increased expression in mice at 2 to 6 months of age. Myelin samples from the central nervous system contain increased levels of MBP citrullination. (J:142650)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:142650 Musse AA, et al., Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech. 2008 Nov;1(4-5):229-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/28/2015
MGI 5.21
The Jackson Laboratory