Trpa1^tm1.1Bju
Targeted Allele Detail

Summary

• Symbol: Trpa1^tm1.1Bju
• Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 1.1, Bradley J Undem
• MGI ID: MGI:4458079
• Gene: Trpa1 Location: Chr1:14942872-14989086 bp, - strand Genetic Position: Chr1, 4.5 cM
• Alliance: Trpa1^tm1.1Bju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161343
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site as inserted upstream of exon 21 and an frt and loxP flanked neo cassette was inserted downstream of exon 21. Cre mediated recombination removed exon 21 and the neo cassette. The absence of transcript expression was confirmed by RT-PCR on trigeminal ganglia extracts. (J:161343)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpa1 Mutation: 92 strains or lines available

Notes

ES cell = CR-UK B6 2.1 (C57BL/6J)

References

• Original: J:161343 Taylor-Clark TE, et al., Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol. 2008 Jul 15;586(14):3447-59
• All: 3 reference(s)