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Targeted Allele Detail
Symbol: Adamts12tm1Agno
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12; targeted mutation 1, Agnes Noel
MGI ID: MGI:4457760
Gene: Adamts12  Location: Chr15:11064790-11346867 bp, + strand  Genetic Position: Chr15, 5.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:160778
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 6 and 7 were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR on ovary, mammary gland, uterus, lung, ear, and lymph node extracts. (J:160778)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adamts12 Mutation:  56 strains or lines available
Original:  J:160778 El Hour M, et al., Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis. Oncogene. 2010 May 20;29(20):3025-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory