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Targeted Allele Detail
Symbol: Lmnatm5Lgf
Name: lamin A; targeted mutation 5, Loren G Fong
MGI ID: MGI:4457607
Synonyms: LmnanPLAO
Gene: Lmna  Location: Chr3:88481148-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:160705
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsIntrons 10 and 11 of Lmna were deleted thereby abolishing production of lamin C and producing a only non-farnesylated prelamin A. A point mutation was introduced into exon 12 that changes the cysteine of prelamin A's CaaX motif to a serine (i.e. CSIM to SSIM). (J:160705)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  57 strains or lines available
Original:  J:160705 Davies BS, et al., An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. Hum Mol Genet. 2010 Jul 1;19(13):2682-94
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory