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Tcaptm1Mkc
Targeted Allele Detail
Nomenclature
Symbol: Tcaptm1Mkc
Name: titin-cap; targeted mutation 1, Martin K Childers
MGI ID: MGI:4457372
Gene: Tcap  Location: Chr11:98383811-98384953 bp, + strand  Genetic Position: Chr11, 61.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159687
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6 x 129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a lacZ-neo cassette. The absence of protein expression was confirmed by western blot analysis on muscle extracts. Immunohistochemistry confirmed the absence of protein expression in the liver, brain, and kidney. (J:159687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcap Mutation:  1 strain or line available
References
Original:  J:159687 Markert CD, et al., Functional muscle analysis of the Tcap knockout mouse. Hum Mol Genet. 2010 Jun 1;19(11):2268-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory