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Dnm1tm2.1Pdc
Targeted Allele Detail
Nomenclature
Symbol: Dnm1tm2.1Pdc
Name: dynamin 1; targeted mutation 2.1, Pietro De Camilli
MGI ID: MGI:4457321
Synonyms: Dnm1LoxP
Gene: Dnm1  Location: Chr2:32308471-32353338 bp, - strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161127
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6 x 129S1/SvImJ)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 2-4 were flanked by loxP sites and an FRT-flanked neomycin resistance cassette was placed in intron 1. Flp mediated recombination removed the neo cassette leaving exons 2 through 4 floxed. (J:161127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnm1 Mutation:  4 strains or lines available
References
Original:  J:161127 Ferguson SM, et al., Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell. 2009 Dec;17(6):811-22
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory