Slc39a1^tm1(KOMP)Mbp
Targeted Allele Detail

Summary

• Symbol: Slc39a1^tm1(KOMP)Mbp
• Name: solute carrier family 39 (zinc transporter), member 1; targeted mutation 1, Mouse Biology Program, UC Davis
• MGI ID: MGI:4456562
• Gene: Slc39a1 Location: Chr3:90155512-90160923 bp, + strand Genetic Position: Chr3, 39.21 cM
• Alliance: Slc39a1^tm1(KOMP)Mbp page
• IMPC: Slc39a1 gene page

Mutation origin

• Mutant Cell Lines: DEPD00501_6_A09, DEPD00501_6_A10, DEPD00501_6_A12, DEPD00501_6_B09, DEPD00501_6_B11, DEPD00501_6_B12, DEPD00501_6_C09, DEPD00501_6_C11, DEPD00501_6_C12, DEPD00501_6_D10, DEPD00501_6_D11, DEPD00501_6_D12, DEPD00501_6_E10, DEPD00501_6_E12, DEPD00501_6_F10, DEPD00501_6_F11, DEPD00501_6_F12, DEPD00501_6_G11, DEPD00501_6_G12, DEPD00501_6_H09, DEPD00501_6_H10, DEPD00501_6_H11
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3078 starting at position 90156606 and ending at position 90159684 of Chromosome 3 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Slc39a1 Mutation: 23 strains or lines available

References

• Original: J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010
• All: 2 reference(s)