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Il6ratm1.1Drew
Targeted Allele Detail
Nomenclature
Symbol: Il6ratm1.1Drew
Name: interleukin 6 receptor, alpha; targeted mutation 1.1, Angela Drew
MGI ID: MGI:4456449
Synonyms: Il6rlox
Gene: Il6ra  Location: Chr3:89869324-89913196 bp, - strand  Genetic Position: Chr3, 39.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160966
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 4, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 6 of the interleukin 6 receptor alpha chain (Il6ra) gene. Flp mediated recombination removed the neo cassette leaving exons 4 through 6 floxed. (J:160966)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il6ra Mutation:  23 strains or lines available
References
Original:  J:160966 McFarland-Mancini MM, et al., Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol. 2010 Jun 15;184(12):7219-28
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory