Fgf3^tm2.1Sms
Targeted Allele Detail

Summary

• Symbol: Fgf3^tm2.1Sms
• Name: fibroblast growth factor 3; targeted mutation 2.1, Suzanne L Mansour
• MGI ID: MGI:4456397
• Synonyms: Fgf3^Pc
• Gene: Fgf3 Location: Chr7:144392349-144397085 bp, + strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fgf3^tm2.1Sms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160254
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A construct containing tetracycline response elements with an antisense CMV promoter element and an frt flanked neo cassette was inserted into intron 1. In addition, exon 2 was flanked by loxP sites. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:160254)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf3 Mutation: 16 strains or lines available

References

• Original: J:160254 Urness LD, et al., FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. Dev Biol. 2010 Apr 15;340(2):595-604
• All: 1 reference(s)