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Targeted Allele Detail
Symbol: Kcne3tm1.1Tjj
Name: potassium voltage-gated channel, Isk-related subfamily, gene 3; targeted mutation 1.1, Thomas J Jentsch
MGI ID: MGI:4456241
Gene: Kcne3  Location: Chr7:100176507-100184869 bp, + strand  Genetic Position: Chr7, 54.33 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:160721
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre mediated recombination removed exon 4 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on jejunum, ileum. colon, stomach, and trachea extracts. (J:160721)
Generation of the Kcne3tm1Tjj and Kcne3tm1.1Tjj alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcne3 Mutation:  1 strain or line available
Original:  J:160721 Preston P, et al., Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport. J Biol Chem. 2010 Mar 5;285(10):7165-75
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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