Irf4^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf4^m1Btlr
• Name: interferon regulatory factor 4; mutation 1, Bruce Beutler
• MGI ID: MGI:4456226
• Synonyms: honey
• Gene: Irf4 Location: Chr13:30933209-30950959 bp, + strand Genetic Position: Chr13, 13.28 cM, cytoband A3.3
• Alliance: Irf4^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is an A to T transversion at nucleotide position 358 of the mRNA sequence, in the third of the gene's 9 exons (Genbank record NM_013674). It results in replacement of arginine by serine at amino acid position 96 of the protein (R96S), in the alpha3 helix of the DNA binding domain. (J:160882) Additional incidental mutations were detected in sequencing for the causative mutation, Irf4^m1Btlr, and may be present in stocks carrying this mutation.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf4 Mutation: 27 strains or lines available

References

• Original: J:160882 Arnold CM, et al., Honey is an allele of Irf4 and causes defects in B cell development and function. MGI Direct Data Submission. 2010
• All: 2 reference(s)