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Acdtm1.2Cek
Targeted Allele Detail
Nomenclature
Symbol: Acdtm1.2Cek
Name: adrenocortical dysplasia; targeted mutation 1.2, Catherine Keegan
MGI ID: MGI:4456178
Synonyms: Acdtm1.2Tdl, TPP1DEL
Gene: Acd  Location: Chr8:105698159-105701095 bp, - strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160503
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCr)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exons 3 through 8 from Tpp1tm1.1Tdl. The predicted protein is expected to be severely truncated containing the N-terminal 79 amino acids and 17 out-of-frame amino acids prior to a stop codon. (J:160503)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acd Mutation:  3 strains or lines available
References
Original:  J:160503 Kibe T, et al., Telomere protection by TPP1 is mediated by POT1a and POT1b. Mol Cell Biol. 2010 Feb;30(4):1059-66
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory