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Gdnftm1.1Neas
Targeted Allele Detail
Nomenclature
Symbol: Gdnftm1.1Neas
Name: glial cell line derived neurotrophic factor; targeted mutation 1.1, Neil A Shneider
MGI ID: MGI:4456155
Synonyms: GDNFFLOX
Gene: Gdnf  Location: Chr15:7840327-7867056 bp, + strand  Genetic Position: Chr15, 3.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160727
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo cassette was inserted upstream of a modified exon 3 in which the coding sequence was floxed. Flp mediated recombination removed the neo cassette leaving the coding sequence floxed. (J:160727)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdnf Mutation:  10 strains or lines available
References
Original:  J:160727 Shneider NA, et al., Gamma motor neurons express distinct genetic markers at birth and require muscle spindle-derived GDNF for postnatal survival. Neural Dev. 2009;4:42
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory