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Tg(Neurog1-cre)1Jejo
Transgene Detail
Nomenclature
Symbol: Tg(Neurog1-cre)1Jejo
Name: transgene insertion 1, Jane E Johnson
MGI ID: MGI:4455179
Synonyms: N1457-Cre, Neurog1457-Cre, Ngn1::Cre
Transgene: Tg(Neurog1-cre)1Jejo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL/J)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe Neurog1 coding region in the BAC RP23 457E22 was replaced by recombineering methods with the coding sequence for cre recombinase. Pronuclear injection of the construct into (C57BL/6J x SJL/J)F1 fertilized eggs was used to generated transgenic mice. Founder mice were subsequently established. The transgenic mice were then bred to outbred ICR mice. When crossed with a reporter strain, cre activity mimics the endogenous gene expression patterns in specific populations of interneurons and some motor neurons in the neural tube between embryonic days 10-13. Also, Cre recombination occurs in Neurog1 lineages that include subpopulations of neurons in the olfactory bulb, hippocampus, cortex, thalamus, midbrain, cerebellum, and dorsal root and cranial ganglia. (J:160255)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neurog1     Summary of all recombinase alleles driven by Neurog1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:160255 Quinones HI, et al., Neurogenin 1 (Neurog1) expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages. Dev Biol. 2010 Apr 15;340(2):283-92
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory