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Il4ratm3.1Tch
Targeted Allele Detail
Nomenclature
Symbol: Il4ratm3.1Tch
Name: interleukin 4 receptor, alpha; targeted mutation 3.1, Talal A Chatila
MGI ID: MGI:4455123
Synonyms: Il4raF709, IL-4Ra Y709F
Gene: Il4ra  Location: Chr7:125151443-125178646 bp, + strand  Genetic Position: Chr7, 68.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:160806
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsTwo base pair substitutions (A->T and C->T at basepair 2362 and 2363, respectively) were introduced into the murine Il4ra cDNA using site-directed mutagenesis. These mutations result in a single amino acid substitution of tyrosine to phenylalanine at codon 709 (Y709F) within the canonical immunoreceptor tyrosine-based inhibitory motif (ITIM) sequence near the carboxyl-terminus of the protein. The targeting vector included these two mutations and a loxP-flanked neo cassette inserted into intron 11. Cre mdiated recombination removed the neo cassette. (J:160806)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4ra Mutation:  28 strains or lines available
References
Original:  J:160806 Tachdjian R, et al., In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol. 2010 May;125(5):1128-1136.e8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory