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Cd226tm1.1Cln
Targeted Allele Detail
Nomenclature
Symbol: Cd226tm1.1Cln
Name: CD226 antigen; targeted mutation 1.1, Marco Colonna
MGI ID: MGI:4454325
Synonyms: DNAM-1-
Gene: Cd226  Location: Chr18:89176967-89272229 bp, + strand  Genetic Position: Chr18, 59.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:159749
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons two and three, encoding the start site and first 129 amino acids, were replaced by a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:159749)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd226 Mutation:  22 strains or lines available
References
Original:  J:159749 Gilfillan S, et al., DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors. J Exp Med. 2008 Dec 22;205(13):2965-73
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory